Freddie Partridge
School of Life Sciences, University of Westminster
ORCiD]Publications
Coghlan A*, Partridge FA*, Duque-Correa MA*, Rinaldi
G*, Clare S, Seymour L, Brandt C, Mkandawire TT, McCarthy C, Holroyd N,
Nick M, Brown AE, Tonitiwong S, Sattelle DB, Berriman M (*contributed
equally)
A drug
repurposing screen for whipworms informed by comparative
genomics.
PLoS Negl Trop Dis 2023 17(9): e0011205. [link] [pdf] [preprint]
Nick M, Partridge FA, Forman R, Bataille CJR, Else
KJ, Russell AJ, Sattelle DB
Screening
the Medicines for Malaria Venture (MMV) Pandemic Response Box chemical
library on Caenorhabditis elegans identifies re-profiled
candidate anthelmintic drug leads
Front. Trop. Dis. 2022 3:1017900. doi:
10.3389/fitd.2022.1017900 [link]
[pdf] [preprint]
Forman R, Partridge FA, Sattelle DB, Else KJ
Un-‘Egg’-Plored:
Characterisation of Embryonation in the Whipworm Model Organism
Trichuris muris
Frontiers in Tropical Diseases 2021 2, 45 [link]
[pdf]
Partridge FA*, Poulton BC*, Lake, MAI*, Lees, RA,
Mann H-J, Lycett GJ, Sattelle DB (*contributed equally)
Actions of
camptothecin derivatives on larvae and adults of the arboviral vector
Aedes aegypti
Molecules 2021 26, 6226 [link] [pdf] [preprint]
Buckingham SD*, Partridge FA*, Poulton BC*, Miller
BS*, McKendry RA, Lycett GJ, Sattelle DB (*contributed equally)
Automated
phenotyping of mosquito larvae enables high-throughput screening for
novel larvicides and smartphone-based detection of larval insecticide
resistance
PLOS Negl Trop Dis 2021 15(6): e0008639 [link]
[pdf] [preprint]
Partridge FA*, Forman R*, Bataille CJR*, Wynne GM,
Nick M, Russell AJ, Else KJ, Sattelle DB (*contributed equally)
Anthelmintic
drug discovery: target identification, screening methods and the role of
open science
Beilstein J. Org. Chem. 2020 16, 1203–1224. [link]
[pdf]
Faravelli G*, Raimondi S*, Marchese L, Partridge FA,
Soria C, Mangione PP, Canetti D, Perni M, Aprile FA, Zorzoli I, Di
Schiavi E, Lomas DA, Bellotti V, Sattelle DB, Giorgetti S (*contributed
equally)
C.
elegans expressing D76N β2-microglobulin: a model for
in vivo screening of drug candidates targeting
amyloidosis.
Sci Rep 2019 9, 1–10 [link] [pdf]
Matthews BJ*, Dudchenko O*, Kingan SB*, Koren, S, Antoshechkin I,
Crawford JE, Glassford WJ, Herre M, Redmond SN, Rose NH, Weedall GD, Wu
Y, Batra SS, Brito-Sierra CA, Buckingham SD, Campbell CL, Chan S, Cox E,
Evans BR, Fansiri T, Filipovic I, Fontaine A, Gloria-Soria A, Hall R,
Joardar VS, Jones AK, Kay RGG, Kodali V, Lee J, Lycett GJ, Mitchell SN,
Muehling J, Murphy MR, Omer AD, Partridge FA, Peluso P,
Aiden AP, Ramasamy V, Rašić G, Roy S, Saavedra-Rodriguez K, Sharan S,
Sharma A, Smith ML, Turner J, Weakley AM, Zhao Z, Akbari OS, Black WC,
Cao H, Darby AC, Hill CA, Johnston JS, Murphy TD, Raikhel AS, Sattelle
DB, Sharakhov IV, White BJ, Zhao L, Aiden EL, Mann RS, Lambrechts L,
Powell JR, Sharakhova MV, Tu Z, Robertson HM, McBride CS, Hastie AR,
Korlach J, Neafsey DE, Phillippy AM, Vosshall LB (*contributed
equally)
Improved reference genome of Aedes aegypti informs arbovirus
vector control. Nature 2018 563:501-507. [link] [pdf] [preprint]
Partridge FA*, Forman R*, Willis NJ*, Bataille CJR*,
Murphy EA, Brown AE, Heyer-Chauhan N, Marinič B, Sowood DJC, Wynne GM,
Else KJ, Russell AJ, Sattelle DB, 2018 (*contributed equally).
2,4-Diaminothieno[3,2-d]pyrimidines, a New Class of
Anthelmintic with Activity against Adult and Egg Stages of Whipworm.
PLoS Negl Trop Dis 2018 12(7):e0006487 [link]
[pdf] [preprint]
Furutani S*, Ihara M*, Lees K*, Buckingham SD*, Partridge
FA, David JA, Patel R, Warchal S, Mellor IR, Matsuda K,
Sattelle DB. (*contributed equally)
The fungal alkaloid Okaramine-B activates an L-glutamate-gated chloride
channel from Ixodes scapularis, a tick vector of Lyme disease.
International Journal for Parasitology: Drugs and Drug
Resistance. 2018 8(2):350-360 [link] [pdf]
Partridge FA*, Brown AE*, Buckingham SD*, Willis NJ,
Wynne GM, Forman R, Else KJ, Morrison AA, Matthews JB, Russell AJ, Lomas
DA, Sattelle DB (*contributed equally)
An automated high-throughput system for phenotypic screening of chemical
libraries on C. elegans and parasitic nematodes.
International Journal for Parasitology: Drugs and Drug
Resistance 2018 8(1):8-21 [link] [pdf] [preprint]
Partridge FA*, Murphy EA*, Willis NJ*, Bataille CJ,
Forman R, Heyer-Chauhan N, Marinič B, Sowood DJ, Wynne GM, Else KJ,
Russell AJ, Sattelle DB (*contributed equally)
Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new
anthelmintic chemotype immobilising whipworm and reducing infectivity
in vivo. PLoS Negl Trop Dis. 2017 Feb
9;11(2):e0005359. [link] [pdf]
Buckingham SD, Partridge FA, Sattelle DB. Automated, high-throughput, motility analysis in Caenorhabditis elegans and parasitic nematodes: Applications in the search for new anthelmintics. Int J Parasitol Drugs Drug Resist. 2014 Oct 30;4(3):226-32. [link]
Hurst RJ, Hopwood T, Gallagher AL, Partridge FA, Burgis T, Sattelle DB, Else KJ. An antagonist of the retinoid X receptor reduces the viability of Trichuris muris in vitro. BMC Infect Dis. 2014 Sep 27;14:520. [link]
Anderson A, Laurenson-Schafer H, Partridge FA, Hodgkin J, McMullan R. Serotonergic chemosensory neurons modify the C. elegans immune response by regulating G-protein signaling in epithelial cells. PLoS Pathog. 2013;9(12):e1003787. [link]
Partridge FA, Gravato-Nobre MJ, Hodgkin J. Signal transduction pathways that function in both development and innate immunity. Dev Dyn. 2010 May;239(5):1330-6. [link]
Hodgkin J, Partridge FA. Caenorhabditis elegans meets microsporidia: the nematode killers from Paris. PLoS Biol. 2008 Dec 23;6(12):2634-7 [link]
Partridge FA, Tearle AW, Gravato-Nobre MJ, Schafer WR, Hodgkin J. The C. elegans glycosyltransferase BUS-8 has two distinct and essential roles in epidermal morphogenesis. Dev Biol. 2008 May 15;317(2):549-59. [link]
Software
INVAPP / Paragon An automated system for analysing worm movement/growth from movies. [doi]